Assistant Professor Nathan Harmston previously worked as a Senior Research Fellow at Duke-NUS Medical school in Singapore. Prior to moving to Singapore, he worked at the MRC Clinical Sciences Centre at Hammersmith Hospital in London. He completed his PhD in 2013 and his MSc in Bioinformatics and Systems Biology in 2008 from Imperial College London. Prior to this he obtained a BSc (Hons) in Computer Science from Nottingham University.
Asst Prof Harmston is a computational biologist who is interested in understanding how gene expression is regulated during both development and in disease; specifically cancer. Asst Prof Harmston uses a number of computational and statistical approaches to ask and answer questions about biological systems, often in close collaboration with experimental biologists.
Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease. Ferrari Bardile, C., Garcia-Miralles, M., Caron, N. S., Rayan, N. A., Langley, S. R., Harmston, N., Rondelli, A. M., Teo, R. T. Y., Waltl, S., Anderson, L. M., Bae, H.-G., Jung, S., Williams, A., Prabhakar, S., Petretto, E., Hayden, M. R., and Pouladi, M. A. (2019). Proceedings of the National Academy of Sciences of the United States of America, 85:201818042
Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing. Bagnati, M., Moreno-Moral, A., Ko, J.-H., Nicod, J., Harmston, N., Imprialou, M., Game, L., Gil, J., Petretto, E., and Behmoaras, J. (2019). JCI insight, 4(2):71
Temporal dynamics of Wnt-dependent transcriptome reveals an oncogenic Wnt/MYC/ribosome axis. Madan*, B., Harmston, N.*, Nallan, G., Montoya, A., Faull, P., Petretto, E., and Virshup, D. M. (2018). The Journal of clinical investigation
Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation. Harmston, N., Ing-Simmons, E., Tan, G., Perry, M., Merkenschlager, M., and Lenhard, B. (2017). Nature Communications, 8(1):441
An embryonic system to assess direct and indirect Wnt transcriptional targets. Suresh*, J., Harmston, N.*, Lim, K. K., Kaur, P., Jin, H. J., Lusk, J. B., Petretto, E., and Tolwinski, N. S. (2017). Scientific Reports, 7(1):11092
Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Madan, B., Ke, Z., Harmston, N., Ho, S. Y., Frois, A. O., Alam, J., Jeyaraj, D. A., Pendharkar, V., Ghosh, K., Virshup, I. H., Manoharan, V., Ong, E. H. Q., Sangthongpitag, K., Hill, J., Petretto, E., Keller, T. H., Lee, M. A., Matter, A., and Virshup, D. M. (2015). Oncogene
GenomicInteractions: An R/Bioconductor package for manipulating and investigating chromatin interaction data. Harmston, N.*, Ing-Simmons* , E., Perry* , M., Baresic, A., and Lenhard, B. (2015). BMC Genomics, 16(1):963
The mystery of extreme non-coding conservation. Harmston, N.*, Baresic*, A., and Lenhard, B. (2013). Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368(1632)
Chromatin and epigenetic features of long-range gene regulation. Harmston, N. and Lenhard, B. (2013). Nucleic Acids Research, 41(15):7185–7199
Which species is it? Species-driven gene name disambiguation using random walks over a mixture of adjacency matrices. Harmston, N., Filsell, W., and Stumpf, M. P. H. (2012). Bioinfor- matics (Oxford, England), 28(2):254–260
Scientific Inquiry 1
Introduction to Computational and Systems Biology