Chan Kiat Hwa

Science (Chemistry)

Assistant Professor

Email: kiathwa.chan@yale-nus.edu.sg

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Dr Chan Kiat Hwa received his doctorate in Chemistry from Princeton University in 2010, under the auspices of an Agency for Science, Technology and Research (A*STAR) National Science Scholarship (PhD), after working on developing chemical tools to explore iron trafficking by Mycobacterium tuberculosis in human macrophages. Thereafter, and prior to joining Yale-NUS College, he carried out postdoctoral research at the Institute of Bioengineering and Nanotechnology, A*STAR, where he worked on exploring the versatile properties of water-based peptide gels in biomaterial applications. His current research interests include probing the impact of select bioorganometallic molecules on cellular processes, as well as the development of water-based organometallic gels for studying gelation. Dr Chan loves badminton and detective fiction, and hopes to promote the detective spirit of inquiry in his classes.

Dr Chan is interested in exploring and developing bioorganometallic compounds for the modulation of cellular processes in select diseases. Carbon monoxide and nitric oxide are known regulators of many cellular processes, so bioorganometallic compounds containing these molecules could modulate cellular responses during disease. However, the detoxification enzymes of the liver can potentially destroy these bioorganometallic compounds. Thus, it is essential to understand the action of liver enzymes on these compounds so that effective bioorganometallic therapeutics can be developed.

Dr Chan is also interested in studying the gelation, as well as molecular self-assembly, of select organometallic compounds. Of particular interest is how various factors, e.g. structural geometry and hydrogen bonding, affect molecular self-assembly and gelation. Such factors can be easily varied in organometallic compounds, thus allowing the curious yet ubiquitous phenomenon of gelation to be studied systematically.

Chan, K. H.*; Lee, W. H.; Ni, M.; Loo, Y.; Hauser, C. A. E. “C-Terminal residue of ultrashort peptides impacts on molecular self-assembly, hydrogelation, and interaction with small-molecule drugs” Scientific Reports 2018, 8, 17127 doi: 10.1038/s41598-018-35431-2 (1-14).

Chan, K. H.*; Xue, B.; Robinson, R. C.; Hauser, C. A. E. “Systematic single moiety variations of ultrashort peptides produce profound effects on self-assembly, nanostructure formation, hydrogelation, and phase transition” Scientific Reports 2017, 7, 12897 doi:10.1038/s41598-017-12694-9 (1-11).

Chan, K. H.; Lee, W. H.; Zhuo, S.; Ni, M. “Harnessing supramolecular peptide nanotechnology in biomedical applications” International Journal of Nanomedicine 2017, 12, 1171-1182.

Ren, C.; Ng, G. H. B.; Wu, H.; Chan, K. H.; Shen, J.; Teh, C.; Ying, J. Y.; Zeng, H. “Instant room-temperature gelation of crude oil by chiral organogelators” Chemistry of Materials 2016, 28, 4001-4008.

Chan, K. H.; Leong, W. K. “Bonding and reactivity of arene-trinuclear ruthenium/osmium clusters” In: Reedijk, J. (Ed.) Elsevier Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Waltham, MA: Elsevier. 29 October 2015 doi: 10.1016/B978-0-12-409547-2.11708-1 (1-10).

Chan, K. H.; Zhuo, S.; Ni, M. “Priming the surface of orthopedic implants for osteoblast attachment in bone tissue engineering” International Journal of Medical Science 2015, 12, 701-707.

Smadbeck, J.**; Chan, K. H.**; Khoury, G. A.**; Xue, B.; Robinson, R. C.; Hauser, C. A. E.; Floudas, C. A. “De novo design and characterization of ultrashort self-associating peptides” PLoS Computional Biology 2014, 10, e1003718 (1-17). (** Co-first author)

Reithofer, M. R.; Chan, K. H.; Lakshmanan, A.; Lam, D. H.; Mishra, A.; Gopalan, B.; Joshi, M.; Wang, S.; Hauser, C. A. E. “Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy” Chemical Science 2014, 5, 625-630.

Mishra, A.**; Chan, K. H.**; Reithofer, M. R.; Hauser, C. A. E. “Influence of metal salts on the hydrogelation properties of ultrashort aliphatic peptides” RSC Advances 2013, 3, 9985-9993. (** Co-first author)

Zhang, S.; Chan, K. H.; Prud’homme, R. K.; Link, A. J. “Synthesis and evaluation of clickable block copolymers for targeted nanoparticle drug delivery” Molecular Pharmaceutics 2012, 9, 2228-2236.

Chan, K. H.; Leong, W. K.; Jaouen, G.; Leclerq, L.; Top, S.; Vessieres, A. “Organometallic cluster analogues of tamoxifen: Synthesis and biochemical assay” Journal of Organometallic Chemistry 2006, 691, 9-19.

Chan, K. H.; Leong, W. K.; Mak, K. H. G. “Thermolysis of the osmium-antimony clusters Os3(CO)11(SbMe2Ar): Higher nuclearity clusters and arrested orthometalation” Organometallics 2006, 25, 250-259.

Foundations of Science
Scientific Inquiry 2
Independent Reading and Research
Physical Chemistry
Inorganic Chemistry
Organometallic Chemistry